Ribosomal small subunit assembly

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPH1, WDR73, and ZKSCAN4, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit assembly activity versus HNRNPH1 in UVM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	HNRNPH1 →	+1.699	+0.063	<.001	<.001	3	27
UVM	WDR73 →	+0.711	+0.063	<.001	<.001	3	26
KICH	ZKSCAN4 →	+0.753	+0.041	<.001	<.001	3	26
UVM	TUT4 →	+1.128	+0.062	<.001	<.001	3	26
UVM	TRIM38 →	+1.096	+0.053	<.001	<.001	3	26
UVM	SRSF6 →	+1.607	+0.064	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000028 vs HNRNPH1 — UVM

Explore this scatter interactively →