Ribosomal small subunit assembly

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNBL1, PHF3, and DHX35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit assembly activity versus CTNNBL1 in LSCC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CTNNBL1 →	+0.299	+0.063	<.001	<.001	3	5
LSCC	PHF3 →	+0.299	+0.047	<.001	<.001	3	5
LSCC	DHX35 →	+0.301	+0.047	<.001	<.001	3	4
PDAC	SRSF12_S167 →	+0.644	+0.042	<.001	<.001	3	4
PDAC	SRSF12_T169 →	+0.644	+0.042	<.001	<.001	3	4
LSCC	GPATCH1 →	+0.244	+0.034	.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000028 vs CTNNBL1 — LSCC

Explore this scatter interactively →