Ribosomal small subunit assembly

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YTHDF3, MEPCE, and SPATA33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YTHDF3 grouped by Ribosomal small subunit assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	YTHDF3 →	-0.680	-0.200	.005	<.001	3	4
CNS	MEPCE →	-0.587	-0.246	.002	.009	3	4
CNS	SPATA33 →	-0.591	-0.171	.002	.003	3	4
CNS	CD2BP2 →	-0.631	-0.213	.005	.009	3	4
CNS	POLR2J →	-0.925	-0.311	<.001	.001	3	4
LUNG_NSCLC_LUAD	RIT1 →	-1.059	-0.339	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YTHDF3 by Ribosomal small subunit assembly activity — LUNG_SCLC

Explore this box plot interactively →