Ribosomal small subunit assembly

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP7A, MCAT, and POLR3H, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit assembly activity versus RRP7A in BLOOD_Myeloma (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RRP7A →	+1.364	+0.112	<.001	<.001	3	16
BLOOD_Myeloma	MCAT →	+1.111	+0.108	<.001	<.001	3	12
BLOOD_Lymphoma	POLR3H →	+0.989	+0.056	<.001	<.001	3	12
BLOOD_Lymphoma	NLE1 →	+1.008	+0.073	<.001	<.001	3	11
LIVER	MRPL46 →	+0.765	+0.058	.004	.005	3	11
BLOOD_Lymphoma	GRWD1 →	+1.223	+0.043	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000028 vs RRP7A — BLOOD_Myeloma

Explore this scatter interactively →