Ribosomal small subunit assembly

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBNL1, UBR1, and AP3D1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit assembly activity versus MBNL1 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MBNL1 →	+0.877	+0.303	<.001	.009	3	5
OVARY	UBR1 →	+0.656	+0.263	.003	.001	2	6
OVARY	AP3D1 →	+0.713	+0.261	.002	<.001	3	5
LARGE_INTESTINE	COPS4 →	+0.849	+0.231	<.001	<.001	3	5
BREAST	YWHAQ →	+0.758	+0.214	.001	.004	3	5
SKIN	P4HB →	+0.797	+0.163	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000028 vs MBNL1 — URINARY_TRACT

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