Ribosomal large subunit assembly

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO1, ADNP, and CMSS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit assembly activity versus XPO1 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO1 →	+0.190	+0.064	<.001	<.001	3	7
LSCC	ADNP →	+0.519	+0.093	<.001	<.001	3	7
LSCC	CMSS1 →	+0.530	+0.049	<.001	<.001	3	7
UCEC	DDX18 →	+0.392	+0.100	<.001	<.001	3	7
BRCA	PLIN3 →	-0.402	-0.038	<.001	<.001	3	7
LSCC	BYSL →	+0.484	+0.089	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000027 vs XPO1 — LSCC

Explore this scatter interactively →