Ribosomal large subunit assembly

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, CDC6, and CDCA3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit assembly activity versus MYBL2 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYBL2 →	+1.068	+0.230	<.001	<.001	3	8
BRCA	CDC6 →	+1.091	+0.312	<.001	<.001	3	8
LUAD	CDCA3 →	+0.981	+0.324	<.001	<.001	3	8
BRCA	MSRB3 →	-0.968	-0.280	<.001	<.001	3	8
LUAD	TROAP →	+0.914	+0.233	.001	.001	3	7
LSCC	CDCA5 →	+0.969	+0.257	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000027 vs MYBL2 — CCRCC

Explore this scatter interactively →