Ribosomal large subunit assembly

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP20, RRP1, and WDR36, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit assembly activity versus UTP20 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UTP20 →	+0.365	+0.113	<.001	.002	3	9
BRCA	RRP1 →	+0.436	+0.335	<.001	<.001	3	8
OV	WDR36 →	+0.385	+0.163	<.001	<.001	2	9
BRCA	BOP1 →	+0.362	+0.344	<.001	<.001	3	8
BRCA	MYBBP1A →	+0.453	+0.293	<.001	<.001	3	8
OV	NAT10 →	+0.541	+0.192	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000027 vs UTP20 — OV

Explore this scatter interactively →