Ribosomal large subunit assembly

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LXN, ASAP3, and CDK7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LXN grouped by Ribosomal large subunit assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LXN →	-4.676	-0.683	<.001	.001	3	4
LIVER	ASAP3 →	-1.470	-0.497	.002	.001	3	4
STOMACH	CDK7 →	+0.789	+0.198	.005	.008	3	4
OVARY	KMT2B →	-0.785	-0.236	.002	.008	3	4
BLOOD_Lymphoma	CNIH3 →	+1.149	+0.637	.004	.009	3	4
PANCREAS	ACTL6A →	-0.684	-0.327	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LXN by Ribosomal large subunit assembly activity — SOFT_TISSUE

Explore this box plot interactively →