Ribosomal large subunit assembly

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRCC1, POLR1B, and EXOSC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit assembly activity versus KRCC1 in LARGE_INTESTINE (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRCC1 →	-1.354	-0.195	.002	.001	3	8
STOMACH	POLR1B →	+0.619	+0.165	.001	.006	3	7
OVARY	EXOSC2 →	+0.841	+0.168	.001	.007	3	7
SKIN	NPM1 →	+0.880	+0.214	<.001	<.001	3	7
LIVER	IMPDH2 →	+0.881	+0.220	.009	.002	3	6
STOMACH	POLR3G →	+1.268	+0.182	.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000027 vs KRCC1 — LARGE_INTESTINE

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