Mitotic spindle elongation

Across TCGA cell cohorts, RNA activity of the Mitotic spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG9, CHAC2, and EXPH5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMG9 grouped by Mitotic spindle elongation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMG9 →	+1.268	+0.247	<.001	.007	2	6
KIDNEY	CHAC2 →	-0.980	-0.319	.007	.003	3	4
URINARY_TRACT	EXPH5 →	+2.159	+0.294	<.001	<.001	3	4
URINARY_TRACT	FRK →	+1.720	+0.305	.001	<.001	3	4
URINARY_TRACT	RRP9 →	-1.136	-0.333	<.001	.001	3	4
URINARY_TRACT	MSRB3 →	-3.568	-0.294	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMG9 by Mitotic spindle elongation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →