Regulation of mitotic recombination

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic recombination pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC2L, NAT10, and POLR1E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic recombination activity versus NOC2L in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOC2L →	+0.322	+0.034	.001	.006	3	7
BRCA	NAT10 →	+0.259	+0.029	.002	.001	3	7
BRCA	POLR1E →	+0.329	+0.043	.008	.001	3	7
LSCC	UTP14A →	+0.300	+0.063	.001	<.001	3	6
LSCC	CEBPZ →	+0.430	+0.060	<.001	<.001	3	6
CCRCC	NPM1 →	+0.250	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000019 vs NOC2L — BRCA

Explore this scatter interactively →