Regulation of mitotic recombination

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERCC2, TERF2, and FBXW4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERCC2 grouped by Regulation of mitotic recombination-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ERCC2 →	-0.462	-0.684	<.001	.001	3	14
BREAST	TERF2 →	-0.182	-0.510	<.001	.006	3	8
SKIN	FBXW4 →	+0.124	+0.585	.006	.008	3	5
OVARY	PHKB →	-0.162	-0.703	.001	.006	3	4
CNS	CYP3A5 →	+0.180	+1.020	<.001	<.001	3	4
SKIN	KDM5B →	-0.087	-0.901	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERCC2 by Regulation of mitotic recombination activity — LUNG_SCLC

Explore this box plot interactively →