Regulation of mitotic recombination

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic recombination pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALU, CGREF1, and SUSD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALU grouped by Regulation of mitotic recombination-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CALU →	-1.103	-0.300	.001	<.001	3	4
OESOPHAGUS	CGREF1 →	-2.678	-0.249	<.001	.002	3	4
BLOOD_Lymphoma	SUSD1 →	+1.520	+0.261	.006	.002	3	3
STOMACH	SMARCAL1 →	-0.587	-0.418	.003	.001	3	3
STOMACH	CARMIL1 →	+1.205	+0.517	.004	.003	3	3
LIVER	NKRF →	+0.684	+1.344	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALU by Regulation of mitotic recombination activity — OESOPHAGUS

Explore this box plot interactively →