Regulation of mitotic recombination

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX4, GTPBP6, and PTPN12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDX4 grouped by Regulation of mitotic recombination-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRDX4 →	+0.111	+1.971	<.001	<.001	3	4
BONE	GTPBP6 →	+0.225	+1.858	.001	<.001	3	4
BLOOD_Leukemia	PTPN12 →	-0.174	-1.305	<.001	<.001	3	4
CNS	ABHD2 →	+0.291	+1.366	.001	<.001	3	3
STOMACH	ZNF114 →	-0.169	-2.010	.003	<.001	3	3
LUNG_NSCLC_LUSC	SCUBE2 →	+0.264	+1.507	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDX4 by Regulation of mitotic recombination activity — STOMACH

Explore this box plot interactively →