Regulation of mitotic recombination

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic recombination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AASDHPPT, MRE11, and CARM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic recombination activity versus AASDHPPT in SKIN (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AASDHPPT →	+0.747	+1.227	.001	<.001	3	5
LUNG_NSCLC_LUAD	MRE11 →	+0.491	+0.945	.009	.002	2	6
OESOPHAGUS	CARM1 →	+0.932	+1.304	<.001	<.001	3	4
LIVER	BCAS3 →	+1.276	+1.433	.001	.001	3	4
BREAST	DAP3 →	+0.707	+1.169	<.001	<.001	3	4
BONE	UBQLN4 →	+0.780	+1.281	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000019 vs AASDHPPT — SKIN

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