Regulation of DNA recombination

Across TCGA patient cohorts, RNA activity of the Regulation of DNA recombination pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TASOR_S1042, ZC3H4_T1106, and POLR1D_S104, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA recombination activity versus TASOR_S1042 in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TASOR_S1042 →	+0.386	+0.314	<.001	<.001	3	2
COAD	ZC3H4_T1106 →	+0.465	+0.445	.001	<.001	3	2
PDAC	POLR1D_S104 →	+0.629	+0.282	<.001	.001	3	2
CCRCC	VIRMA_S1579 →	+0.302	+0.215	<.001	<.001	3	2
OV	FBXO42 →	-0.597	-0.256	.005	.001	3	2
OV	SLC9A1_S703 →	-1.338	-0.226	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000018 vs TASOR_S1042 — PDAC

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