Regulation of DNA recombination

Across TCGA cell cohorts, RNA activity of the Regulation of DNA recombination pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TDRD7, DDX60L, and ABI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TDRD7 grouped by Regulation of DNA recombination-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TDRD7 →	+0.956	+0.130	.001	.002	3	5
LUNG_SCLC	DDX60L →	+1.011	+0.132	.005	.009	3	5
BLOOD_Leukemia	ABI2 →	-1.332	-0.133	.008	.009	3	5
LUNG_NSCLC_LUAD	KLRG1 →	-0.762	-0.111	<.001	.001	3	5
URINARY_TRACT	LIPG →	+4.917	+0.271	.002	<.001	3	5
BLOOD_Lymphoma	FSD1 →	-3.137	-0.178	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TDRD7 by Regulation of DNA recombination activity — OESOPHAGUS

Explore this box plot interactively →