Regulation of DNA recombination

Across TCGA cell cohorts, RNA activity of the Regulation of DNA recombination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, FAM117B, and MSH6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA recombination activity versus NCAPH in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NCAPH →	+0.598	+0.140	.004	<.001	3	6
LUNG_NSCLC_LUSC	FAM117B →	+1.170	+0.212	.008	.003	3	6
BLOOD_Leukemia	MSH6 →	+1.337	+0.098	<.001	<.001	3	6
BLOOD_Leukemia	C17orf75 →	+0.868	+0.095	<.001	.004	3	6
BLOOD_Leukemia	PAIP2 →	+0.900	+0.137	<.001	<.001	3	6
BLOOD_Leukemia	VANGL2 →	+0.975	+0.078	.005	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000018 vs NCAPH — LUNG_NSCLC_LUAD

Explore this scatter interactively →