Single strand break repair

Across TCGA patient cohorts, RNA activity of the Single strand break repair pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMP, POLR1A_T357, and SLK_S571, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Single strand break repair activity versus CAMP in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CAMP →	-1.128	-0.041	<.001	<.001	3	5
OV	POLR1A_T357 →	-0.881	-0.034	.008	.003	3	5
PDAC	SLK_S571 →	-0.369	-0.029	.009	.002	3	4
PDAC	WASHC2A_S550 →	+0.627	+0.040	.004	.003	3	4
PDAC	CDC42BPA_S1545 →	+0.384	+0.031	<.001	<.001	3	4
PDAC	ARHGAP31_S1432 →	+0.703	+0.042	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000012 vs CAMP — LSCC

Explore this scatter interactively →