Single strand break repair

Across TCGA patient cohorts, RNA activity of the Single strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRC1-AS1, GINS2, and COPRS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Single strand break repair activity versus PRC1-AS1 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRC1-AS1 →	+0.474	+0.956	.004	<.001	3	4
GBM	GINS2 →	+0.799	+0.934	.001	<.001	3	3
HNSC	COPRS →	+0.534	+0.546	.009	.004	3	3
LSCC	FAM241B →	+0.420	+0.191	.009	.002	3	3
GBM	LIG1 →	+0.578	+0.983	.002	<.001	3	3
PDAC	NEK2 →	+0.358	+0.401	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000012 vs PRC1-AS1 — GBM

Explore this scatter interactively →