Single strand break repair

Across TCGA cell cohorts, RNA activity of the Single strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD9, HERC4, and LYSMD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Single strand break repair activity versus PSMD9 in SOFT_TISSUE (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSMD9 →	-0.783	-0.184	<.001	<.001	3	4
SOFT_TISSUE	HERC4 →	-1.346	-0.223	.001	<.001	3	4
LIVER	LYSMD2 →	-1.932	-0.218	.001	.002	2	5
LIVER	ARMC9 →	-1.424	-0.188	.009	.002	3	4
LIVER	VASH2 →	+1.902	+0.213	.001	.006	3	4
CNS	HCFC2 →	-0.699	-0.132	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000012 vs PSMD9 — SOFT_TISSUE

Explore this scatter interactively →