ZZZ3

Across TCGA pan-cancer cohorts, ZZZ3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZZZ3 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZZZ3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZZZ3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where ZZZ3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.857	0.520	.003	24	view →
PDAC	OS	Tertile	II,III,IV	0.407	0.668	.010	22	view →
LSCC	OS	Tertile	All	0.884	0.720	.027	5	view →
LUAD	OS	Tertile	II,III,IV	0.299	0.798	.038	4	view →
GBM	DFS	Median	All	0.326	0.197	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZZZ3–CCRCC (DFS)

Open the CCRCC breakdown →