ZZZ3

Across TCGA cell cohorts, ZZZ3 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZZZ3-associated genes across cancer lineages are REG3G, C18orf63, and TEX101. Each is linked with ZZZ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZZZ3-to-partner and partner-to-ZZZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by ZZZ3-low versus ZZZ3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZZ3→partner) and Y-score (partner→ZZZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
STOMACH	TEX101 →	+0.083	+2.754	.004	.003	3	1
STOMACH	ING1 →	+0.637	+3.070	.007	.008	3	1
STOMACH	CRYBA4 →	+0.222	+2.536	<.001	.003	3	1
STOMACH	IFITM5 →	+0.238	+3.211	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

REG3G by ZZZ3 expression — BLOOD_Lymphoma

Explore this box plot interactively →