ZZEF1

Across TCGA patient cohorts, ZZEF1 RNA expression is significantly associated with the mutation status of many other genes, with 10,927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZZEF1-associated genes across cancer lineages are TP53, ISLR2, and CPED1. Each is linked with ZZEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZZEF1-to-partner and partner-to-ZZEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by ZZEF1-low versus ZZEF1-high in PAAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZEF1→partner) and Y-score (partner→ZZEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	TP53 →	-1.428	-0.381	<.001	<.001	3	3
UCEC	ISLR2 →	+2.565	+0.428	<.001	<.001	3	3
UCEC	CPED1 →	+2.958	+0.433	<.001	<.001	3	3
UCEC	MPRIP →	+1.869	+0.520	<.001	<.001	3	3
UCEC	BRIP1 →	+1.732	+0.336	.001	<.001	3	3
UCEC	EPRS1 →	+1.523	+0.436	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,927 associations by consensus.

TP53 by ZZEF1 expression — PAAD

Explore this box plot interactively →