ZZEF1

Across TCGA patient cohorts, ZZEF1 mutation is significantly associated with the RNA expression of many other genes, with 8,686 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZZEF1-associated genes across cancer lineages are UHRF1, CLSPN, and XRCC6. Each is linked with ZZEF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZZEF1-to-partner and partner-to-ZZEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by ZZEF1-low versus ZZEF1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZEF1→partner) and Y-score (partner→ZZEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	UHRF1 →	+1.174	+3.475	<.001	.002	3	5
STAD	CLSPN →	+0.801	+3.475	<.001	.002	3	5
UCEC	XRCC6 →	+0.490	+1.518	<.001	<.001	3	5
UCEC	CHAF1A →	+0.775	+3.072	<.001	<.001	3	5
UCEC	MCM5 →	+0.531	+1.875	<.001	<.001	3	5
STAD	PRMT5 →	+0.760	+3.525	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,686 associations by consensus.

UHRF1 by ZZEF1 expression — STAD

Explore this box plot interactively →