ZZEF1

Across TCGA patient cohorts, ZZEF1 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZZEF1-associated genes across cancer lineages are GAPDH, Cyclin-E2, and Caspase-8. Each is linked with ZZEF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZZEF1-to-partner and partner-to-ZZEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZZEF1-low versus ZZEF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZEF1→partner) and Y-score (partner→ZZEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.570	+1.915	.001	.009	3	5
BLCA	Cyclin-E2 →	+0.150	+1.775	.038	.048	3	4
UCEC	Caspase-8 →	-0.246	-1.621	<.001	<.001	3	4
COAD	INPP4B →	-0.351	-2.000	.009	.029	3	4
STAD	p70-S6K_pT389 →	-0.227	-3.169	.013	.018	3	3
STAD	Src_pY527 →	-0.779	-3.459	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

GAPDH by ZZEF1 expression — COAD

Explore this box plot interactively →