ZYG11B

Across TCGA patient cohorts, ZYG11B mutation is significantly associated with the RNA expression of many other genes, with 2,360 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZYG11B-associated genes across cancer lineages are AKAP5, GINS3, and BRI3BP. Each is linked with ZYG11B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYG11B-to-partner and partner-to-ZYG11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAP5 grouped by ZYG11B-low versus ZYG11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYG11B→partner) and Y-score (partner→ZYG11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKAP5 →	+0.516	+3.321	<.001	<.001	3	2
UCEC	GINS3 →	+0.448	+2.191	.003	.002	3	2
UCEC	BRI3BP →	+0.751	+4.403	<.001	<.001	3	2
UCEC	NF2 →	+0.624	+2.673	<.001	<.001	3	2
UCEC	CALHM6 →	+1.010	+3.711	<.001	<.001	3	2
UCEC	STRN3 →	+0.543	+2.684	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

AKAP5 by ZYG11B expression — UCEC

Explore this box plot interactively →