ZYG11B

Across TCGA patient cohorts, ZYG11B mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZYG11B-associated genes across cancer lineages are eEF2, ERK2, and JNK2. Each is linked with ZYG11B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYG11B-to-partner and partner-to-ZYG11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZYG11B-low versus ZYG11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYG11B→partner) and Y-score (partner→ZYG11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.384	+2.999	.009	.035	3	2
UCEC	ERK2 →	+0.240	+3.000	.002	.001	3	2
UCEC	JNK2 →	+0.203	+1.807	.013	.027	3	2
UCEC	mTOR_pS2448 →	-0.187	-2.565	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.270	-2.584	.009	.010	3	1
UCEC	eIF4E →	+0.219	+3.000	.012	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by ZYG11B expression — UCEC

Explore this box plot interactively →