ZYG11B

Across TCGA cell cohorts, ZYG11B mutation is significantly associated with the drug of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZYG11B-associated genes across cancer lineages are IGF1R_3801, Dactinomycin, and 50869. Each is linked with ZYG11B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYG11B-to-partner and partner-to-ZYG11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGF1R_3801 grouped by ZYG11B-low versus ZYG11B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYG11B→partner) and Y-score (partner→ZYG11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IGF1R_3801 →	+0.618	+2.649	.040	.046	3	1
LARGE_INTESTINE	Dactinomycin →	+0.559	+2.649	.016	.046	3	1
LARGE_INTESTINE	50869 →	+0.433	+2.649	.041	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.531	+2.646	.033	.047	3	1
LARGE_INTESTINE	Zibotentan →	+0.209	+2.652	.039	.045	3	1
LARGE_INTESTINE	Dinaciclib →	+0.520	+2.646	.044	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

IGF1R_3801 by ZYG11B expression — LARGE_INTESTINE

Explore this box plot interactively →