ZXDC

Across TCGA pan-cancer cohorts, ZXDC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZXDC data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZXDC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZXDC expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where ZXDC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.659	1.000	.021	8	view →
LSCC	DFS	Tertile	II,III,IV	0.878	0.541	.021	8	view →
PDAC	DFS	Median	All	0.817	0.355	.024	3	view →
GBM	DFS	Tertile	All	0.385	0.229	.025	3	view →
CCRCC	DFS	Median	II,III,IV	0.526	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZXDC–UCEC (OS)

Open the UCEC breakdown →