ZXDC

Across TCGA patient cohorts, ZXDC mutation is significantly associated with the RNA expression of many other genes, with 1,848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZXDC-associated genes across cancer lineages are LINC01943, SNORD90, and RPL13AP. Each is linked with ZXDC in more than 1 cancer types. Because this analysis shows association rather than direction, both ZXDC-to-partner and partner-to-ZXDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01943 grouped by ZXDC-low versus ZXDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDC→partner) and Y-score (partner→ZXDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01943 →	+0.592	+2.465	<.001	<.001	3	2
BRCA	SNORD90 →	+0.312	+3.747	<.001	.005	3	2
BRCA	RPL13AP →	+0.135	+3.917	.009	.004	3	2
UCEC	LINC01801 →	-0.210	-3.807	.007	<.001	3	2
LUSC	RNA5SP405 →	+0.267	+4.733	<.001	.004	3	2
LUSC	SLC35G4 →	+0.036	+5.102	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,848 associations by consensus.

LINC01943 by ZXDC expression — UCEC

Explore this box plot interactively →