ZXDC

Across TCGA patient cohorts, ZXDC mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZXDC-associated genes across cancer lineages are Rad50, ATM, and Caspase-7-cleavedD198. Each is linked with ZXDC in more than 2 cancer types. Because this analysis shows association rather than direction, both ZXDC-to-partner and partner-to-ZXDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ZXDC-low versus ZXDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDC→partner) and Y-score (partner→ZXDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.267	-2.263	<.001	<.001	3	3
UCEC	ATM →	-0.583	-3.156	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+1.043	+3.087	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.261	+2.837	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.194	-1.652	.019	.006	3	1
UCEC	eIF4E →	+0.203	+2.263	.003	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Rad50 by ZXDC expression — UCEC

Explore this box plot interactively →