ZXDC

Across TCGA cell cohorts, ZXDC mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZXDC-associated genes across cancer lineages are MMD2, OR5AL1, and OR2H1. Each is linked with ZXDC in more than 1 cancer types. Because this analysis shows association rather than direction, both ZXDC-to-partner and partner-to-ZXDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by ZXDC-low versus ZXDC-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDC→partner) and Y-score (partner→ZXDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	OR5AL1 →	+0.023	+5.357	<.001	.003	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
OVARY	GPX5 →	+0.016	+4.228	.007	.006	3	1
SKIN	OR5V1 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PLA2G3 →	+1.189	+3.540	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

MMD2 by ZXDC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →