Across TCGA patient cohorts, ZXDB mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZXDB-associated genes across cancer lineages are A-Raf_pS299, MEK1, and p38-MAPK_pT180_Y182. Each is linked with ZXDB in more than 1 cancer types. Because this analysis shows association rather than direction, both ZXDB-to-partner and partner-to-ZXDB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDB→partner) and Y-score (partner→ZXDB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.081	-1.152	.017	.048	3	2
UCEC	MEK1 →	+0.334	+2.058	.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.404	-1.652	.001	.005	3	2
UCEC	ATM →	-0.326	-1.571	.012	.032	3	2
UCEC	c-Met →	-0.171	-1.787	.047	.003	3	2
UCEC	14-3-3_beta →	-0.071	-1.738	.013	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

ZXDB survival (RNA) · tumor vs normal (RNA) · all ZXDB data types