Across TCGA cell cohorts, ZXDB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,674 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZXDB-associated GO terms across cancer lineages are Random inactivation of X chromosome, Sex-chromosome dosage compensation, and Dosage compensation by inactivation of X chromosome. Each is linked with ZXDB in more than 12 cancer types. Because this analysis shows association rather than direction, both ZXDB-to-partner and partner-to-ZXDB results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDB→partner) and Y-score (partner→ZXDB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Random inactivation of X chromosome →	+0.090	+0.925	<.001	<.001	3	13
LUNG_SCLC	Sex-chromosome dosage compensation →	+0.108	+0.493	.001	.005	3	12
OVARY	Dosage compensation by inactivation of X chromosome →	+0.095	+0.503	<.001	<.001	3	12
SKIN	Post-Golgi vesicle-mediated transport →	+0.062	+0.475	<.001	<.001	3	11
BONE	Negative regulation of DNA-templated transcription initiation →	+0.110	+0.590	<.001	.007	3	11
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.110	+0.590	<.001	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,674 associations by consensus.

Exploration

ZXDB survival (RNA) · tumor vs normal (RNA) · all ZXDB data types