Across TCGA cell cohorts, ZXDB mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZXDB-associated genes across cancer lineages are GSTA5, C9orf92, and RHOXF1. Each is linked with ZXDB in more than 1 cancer types. Because this analysis shows association rather than direction, both ZXDB-to-partner and partner-to-ZXDB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDB→partner) and Y-score (partner→ZXDB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSTA5 →	+0.035	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
SKIN	RHOXF1 →	+0.054	+2.994	.003	.006	3	1
SKIN	DEFB123 →	+0.053	+3.217	<.001	.006	3	1
SKIN	TMEM132C →	+0.025	+3.217	<.001	.006	3	1
SKIN	CLEC9A →	+0.019	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ZXDB survival (RNA) · tumor vs normal (RNA) · all ZXDB data types