Across TCGA cell cohorts, ZXDA mutation is significantly associated with the drug of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZXDA-associated genes across cancer lineages are Crizotinib, Entospletinib, and JAK_8517. Each is linked with ZXDA in more than 1 cancer types. Because this analysis shows association rather than direction, both ZXDA-to-partner and partner-to-ZXDA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZXDA→partner) and Y-score (partner→ZXDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Crizotinib →	+0.484	+2.646	.017	.047	3	1
LARGE_INTESTINE	Entospletinib →	+0.548	+2.646	.003	.047	3	1
LARGE_INTESTINE	JAK_8517 →	+0.802	+2.649	.012	.046	3	1
LARGE_INTESTINE	AZD4547 →	+1.213	+2.646	<.001	.047	3	1
LARGE_INTESTINE	Vinblastine →	+0.919	+2.655	.033	.044	2	1
LARGE_INTESTINE	Olaparib →	+0.374	+2.646	.046	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

ZXDA survival (RNA) · tumor vs normal (RNA) · all ZXDA data types