ZWINT

Across TCGA pan-cancer cohorts, ZWINT Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZWINT data layer compared with 29 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ZWINT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZWINT expression acts as an unfavorable survival marker.

BRCA, BLCA, and ESCA are the cancer types where ZWINT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.110	0.578	.001	24	view →
BLCA	OS	Median	All	0.141	0.687	.003	21	view →
ESCA	DFS	Median	II,III,IV	0.107	0.522	.012	12	view →
LIHC	OS	Median	All	0.156	0.777	.004	12	view →
COAD	OS	Median	II,III,IV	0.163	0.604	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZWINT–BRCA (OS)

Open the BRCA breakdown →