ZWINT

Across TCGA pan-cancer cohorts, ZWINT mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZWINT data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZWINT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZWINT expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where ZWINT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.859	.019	21	view →
LUAD	OS	Quartile	III,IV	0.184	0.839	.004	11	view →
PDAC	DFS	Median	All	0.470	0.991	.038	6	view →
CCRCC	DFS	Quartile	All	0.272	1.000	.042	6	view →
LSCC	DFS	Median	All	0.937	0.559	.009	4	view →
GBM	OS	Quartile	All	1.000	0.607	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZWINT–HNSC (DFS)

Open the HNSC breakdown →