ZWINT

Across TCGA pan-cancer cohorts, ZWINT mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZWINT’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ZWINT mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZWINT is over-expressed in tumor.

LSCC, LUAD, and HNSC are the cancer types where ZWINT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZWINT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+1.173	<.001	9	view →
LUAD	Male	II,III,IV	+0.564	<.001	7	view →
HNSC	All	All	+0.429	.008	6	view →
CCRCC	All	All	+0.675	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZWINT–LSCC

Open the LSCC breakdown →