ZWILCH

Across TCGA pan-cancer cohorts, ZWILCH mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZWILCH’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZWILCH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZWILCH is over-expressed in tumor.

HNSC, LSCC, and CCRCC are the cancer types where ZWILCH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZWILCH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.570	<.001	11	view →
LSCC	Male	II,III,IV	+0.937	<.001	9	view →
CCRCC	All	III,IV	+0.684	<.001	9	view →
LUAD	Male	II,III,IV	+0.575	<.001	7	view →
PDAC	All	III,IV	+0.658	.014	5	view →
OV	All	All	+0.583	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZWILCH–HNSC

Open the HNSC breakdown →