ZWILCH

Across TCGA patient cohorts, ZWILCH mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZWILCH-associated genes across cancer lineages are ERK2, Heregulin, and MEK1. Each is linked with ZWILCH in more than 1 cancer types. Because this analysis shows association rather than direction, both ZWILCH-to-partner and partner-to-ZWILCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZWILCH-low versus ZWILCH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZWILCH→partner) and Y-score (partner→ZWILCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.217	+3.169	.015	.019	3	1
UCEC	Heregulin →	-0.121	-2.584	.036	.011	3	1
UCEC	MEK1 →	+0.365	+2.321	.032	.034	3	1
UCEC	PCNA →	+0.362	+2.584	<.001	.010	3	1
UCEC	Rab25 →	-0.488	-2.999	.001	.035	3	1
UCEC	Rad50 →	-0.246	-3.000	.029	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by ZWILCH expression — UCEC

Explore this box plot interactively →