ZWILCH

Across TCGA cell cohorts, ZWILCH mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZWILCH-associated genes across cancer lineages are Mirin, AZD7969, and Ara-G. Each is linked with ZWILCH in more than 1 cancer types. Because this analysis shows association rather than direction, both ZWILCH-to-partner and partner-to-ZWILCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by ZWILCH-low versus ZWILCH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZWILCH→partner) and Y-score (partner→ZWILCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.471	+2.868	.007	.022	3	1
LARGE_INTESTINE	AZD7969 →	+0.504	+2.871	.019	.021	3	1
LARGE_INTESTINE	Ara-G →	+0.194	+2.944	.014	.018	3	1
LARGE_INTESTINE	Rucaparib →	+0.401	+2.710	.010	.043	1	1
LARGE_INTESTINE	AZD4877 →	+0.759	+2.871	.021	.021	1	1
LARGE_INTESTINE	Eg5_9814 →	+0.650	+2.807	.018	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Mirin by ZWILCH expression — LARGE_INTESTINE

Explore this box plot interactively →