ZUP1

Across TCGA patient cohorts, ZUP1 mutation is significantly associated with the RNA expression of many other genes, with 1,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZUP1-associated genes across cancer lineages are RN7SL198P, IGHD6-19, and IGHD6-25. Each is linked with ZUP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZUP1-to-partner and partner-to-ZUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL198P grouped by ZUP1-low versus ZUP1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZUP1→partner) and Y-score (partner→ZUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL198P →	+0.181	+5.039	<.001	.008	3	2
UCEC	IGHD6-19 →	+0.426	+2.420	.001	.009	3	2
UCEC	IGHD6-25 →	+0.781	+2.706	<.001	<.001	3	2
UCEC	IGHVIII-22-2 →	+0.367	+2.551	.004	.006	3	2
LUAD	OR6C73P →	+0.189	+7.930	<.001	.008	3	2
BLCA	MTCO3P41 →	+0.100	+4.899	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,071 associations by consensus.

RN7SL198P by ZUP1 expression — READ

Explore this box plot interactively →