ZUP1

Across TCGA cell cohorts, ZUP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,953 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible ZUP1-associated GO terms across cancer lineages are Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, and DNA-templated DNA replication maintenance of fidelity. Each is linked with ZUP1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZUP1-to-partner and partner-to-ZUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication grouped by ZUP1-low versus ZUP1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZUP1→partner) and Y-score (partner→ZUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication →	+0.106	+0.699	<.001	<.001	3	16
LUNG_NSCLC_LUSC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.168	+1.065	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.095	+0.782	<.001	<.001	3	15
LUNG_SCLC	Termination of RNA polymerase II transcription →	+0.140	+1.000	<.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.099	+0.629	.001	.002	3	13
OVARY	Ribosomal small subunit export from nucleus →	+0.112	+0.808	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication by ZUP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →