ZUP1

Across TCGA cell cohorts, ZUP1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZUP1-associated genes across cancer lineages are CLDN17, POM121L12, and CD300H. Each is linked with ZUP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZUP1-to-partner and partner-to-ZUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by ZUP1-low versus ZUP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZUP1→partner) and Y-score (partner→ZUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLDN17 →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.030	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CLDN17 by ZUP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →