Across TCGA pan-cancer cohorts, ZSWIM8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZSWIM8 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZSWIM8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZSWIM8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where ZSWIM8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.201	0.609	<.001	43	view →
UCEC	DFS	Tertile	All	1.000	0.805	<.001	28	view →
PDAC	OS	Tertile	III,IV	0.864	0.225	.001	9	view →
CCRCC	OS	Median	II,III,IV	0.907	0.739	.020	7	view →
GBM	OS	Tertile	All	0.667	0.969	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZSWIM8 tumor-vs-normal RNA expression · all ZSWIM8 data types