Across TCGA patient cohorts, ZSWIM8 mutation is significantly associated with the RNA expression of many other genes, with 6,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM8-associated genes across cancer lineages are EIF4E, HK2, and RRAD. Each is linked with ZSWIM8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZSWIM8-to-partner and partner-to-ZSWIM8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM8→partner) and Y-score (partner→ZSWIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF4E →	+0.482	+1.916	<.001	<.001	3	4
UCEC	HK2 →	+0.638	+2.403	<.001	<.001	3	4
CESC	RRAD →	-1.474	-2.312	.009	.005	3	3
BLCA	ECHS1 →	+0.528	+3.227	.004	.008	3	3
UCEC	LINC00641 →	+0.492	+1.846	<.001	<.001	3	3
COAD	ERH →	+0.383	+3.223	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,098 associations by consensus.

Exploration

ZSWIM8 survival (RNA) · tumor vs normal (RNA) · all ZSWIM8 data types