Across TCGA patient cohorts, ZSWIM8 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM8-associated genes across cancer lineages are PCNA, eEF2, and ASNS. Each is linked with ZSWIM8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZSWIM8-to-partner and partner-to-ZSWIM8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM8→partner) and Y-score (partner→ZSWIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.305	+3.000	.005	.035	3	4
UCEC	eEF2 →	+0.235	+1.678	.019	.019	3	3
UCEC	ASNS →	+0.487	+1.632	<.001	<.001	3	3
BLCA	EGFR_pY1068 →	+0.829	+2.182	<.001	.033	3	2
BLCA	FASN →	+0.506	+3.321	.041	.010	3	2
BLCA	HER2_pY1248 →	+0.704	+3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

ZSWIM8 survival (RNA) · tumor vs normal (RNA) · all ZSWIM8 data types